https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Exercise-Induced Left Atrial Hypertension in Heart Failure With Preserved Ejection Fraction https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51281 Wed 30 Aug 2023 09:59:56 AEST ]]> Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47964 70 mm Hg associated with worse outcomes]), right atrial volume index (pinteraction=0·012 [≥29·7 mL/m2, worse outcomes]), and sex (pinteraction=0·02 [men, worse outcomes]). There were no differences in the composite safety endpoint between the two groups (n=116 [38%] for shunt device vs n=97 [31%] for sham procedure; p=0·11). Interpretation: Placement of an atrial shunt device did not reduce the total rate of heart failure events or improve health status in the overall population of patients with heart failure and ejection fraction of greater than or equal to 40%. Funding: Corvia Medical.]]> Mon 13 Feb 2023 15:45:01 AEDT ]]>